Skin Cancer - A World-Wide Perspective
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However, it is not usually included in estimates for global and national cancer rates. The data on non-melanoma skin cancer is usually less accurate and less complete than for other cancers.
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The panel judged the evidence and drew conclusions in March The conclusions drawn form part of the Third Expert Report. In addition to the findings on diet, nutrition and physical activity outlined above, other established causes of skin cancer include:. Medicines used to suppress the immune system after organ transplantation are associated with increased risk of skin cancers, particularly squamous cell carcinoma.
Infection with human papilloma virus can cause squamous cell carcinomas of the skin, especially in people whose immune systems are compromised. Exposure to specific chemicals used in the plastic and chemical industries — polychlorinated biphenyls — is strongly associated with an increased risk of skin cancer. Some rare mutation in specific genes can lead to skin cancer.
Findings on skin cancer
Having a family history of skin cancer also increases risk. Exposure to UV radiation is the primary cause of skin cancer.
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The role of sun damage is supported by the association between measures of sun sensitivity and skin cancer incidence, which is higher in people who have pale skin that burns without tanning, blue eyes and red hair. Both the duration and severity of exposure is important: there is a dose—response relationship between the number of sunburn episodes during any life period childhood, adolescence or adulthood and the risk of melanoma.
UV radiation can induce cellular changes consistent with the hallmarks of cancer, including inducing genomic instability and mutation, resisting cell death, activating sustained proliferative signalling and cell growth, as well as initiating tumour-promoting inflammatory responses. UV radiation can directly damage DNA and also create cellular environments which are damaging to DNA, for example through the generation of reactive oxygen species.
The activation of chronic inflammatory pathways helps generate an environment conducive to cancer development and progression and is associated with progression from actinic keratosis to squamous cell carcinoma. Overall, UV radiation has a range of effects on skin cells, affecting several metabolic pathways that together create a cellular microenvironment conducive to the development and progression of cancer.
He is the author of more than original articles and is a recognized opinion leader in cutaneous oncology worldwide. His research interests are broad and include cutaneous T-cell lymphoma, cutaneous carcinoma, and especially melanoma.
Book Skin Cancer A World Wide Perspective 2011
Professor Pittelkow is the author of numerous scientific articles on diverse aspects of dermatology. His research interests include virus-related lymphomas and autoimmune diseases and he has an impressive publication record. She has served on many Australian research bodies and has also been a chair or member of many committees at the International Agency for Research on Cancer in Lyon, France. Her main area of interest is cancer epidemiology, with a particular focus on melanoma and other skin cancers. Nagwa M.
Professor Elwan is the author of more than 50 research articles on dermatopathology, acne, psoriasis, atopic dermatitis, lymphoma, and leprosy and has been guest speaker at many national and international dermatology meetings. Du kanske gillar. Lifespan David Sinclair Inbunden. Sobotta Atlas of Anatomy, Package, 16th ed. Inbunden Engelska, Spara som favorit. Skickas inom vardagar.
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Skickas inom vardagar specialorder. Over the last decades the incidence of skin cancers is dramatically increasing world-wide.